Phase I

Phase II

Phase III

Phase IV

Multiple sclerosis doesn't hit all women at the same time in life. But it almost always begins before menopause. Symptoms often get worse after childbirth or at the end of a menstrual cycle. When men get MS, it's usually in their 30s or 40s -- just about the time their testosterone levels start to decline. These clues suggest that sex hormones, like estrogen and testosterone, play a role in the disease. It may be the balance of hormones, rather than their actual levels, that's important.

In terms of all types of MS, at least twice as many women as men have the condition. But the ratio may be rising even higher. Some recent estimates place the number at 4 to 1 -- and suggest it is still going up. And ladies are more likely to have their first symptoms at younger ages. Three women for every man got MS before age 20.

If enrolled in the study medication will be divided between treatment groups (cohorts) receiving different doses of ublituximab. There is a 1 in 4 chance that the subject may receive placebo for 28 days prior to receiving ublituximab, but all subjects will eventually receive three doses of ublituximab over the course of 48 weeks. If you are qualified, the Sponsor will issue the cohort assignment to you. You could initially receive placebo, 150 mg, 450 mg or 600 mg of the study drug